More specifically, the little overlap observed between clonotypes from naive and immune libraries might reflect the fact that i) the naive IgM library was generated from the pooled PBMCs obtained from 4 subjects and might therefore contain a higher number of different clonotypes than a library from a single individual, such as our COVID-19 patient libraries and that ii) the libraries obtained from each individual COVID-19 recovered patient might be biologically skewed, displaying a polarisation of the immune response towards SARS-CoV-2 targets. This evidence concerns the gene CD40LG and COVID-19.