IDH1 and central nervous system cancer: Itgb4 expression was lower in IDH1-mutant gliomas compared to IDH1 wild-type gliomas in both LGG and HGG (Fig. 4I–K, P < 0.001), except for GBM in TCGA where there was only a slight decrease with no significant difference (Fig. 4L, P = 0.45, logFC = −0.62).