KD of B2M or use of anti-LILRB1 antibody had no significant impact on ferroptotic cell death (Supplementary Fig. 4a–c), and anti-LILRB1 antibody did not inhibit the colony-formation ability of MM cells (Supplementary Fig. 4d), indicating that LILRB1 may interact with other novel membrane target proteins for its function in lipid peroxidation. Here, B2M is linked to Miyoshi myopathy.