Simvastatin, the 3-hydroxy-3-methylglutaryl-CoA reductase (HMGCR) enzyme inhibitor69, increased ferroptotic cell death induced by RSL3 in both CTR-KD and LILRB1-KD MM cells (Fig. 7d; Supplementary Fig. 7c), while SQLE inhibitors such as terbinafine HCl70 (Fig. 7e; Supplementary Fig. 7d) and NB59871 (Fig. 7f; Supplementary Fig. 7e), which cause the accumulation of squalene, strongly inhibited cell death induced by RSL3 in LILRB1-KD cells, indicating that LILRB1-KD MM cells may have become more sensitive to ferroptosis induction with less squalene. Here, HMGCR is linked to Miyoshi myopathy.