Because sepsis is considered one of the main risk factors for ICUAW, multiple cytokines, including tumor necrosis factor-α (TNFα), interleukin-1 (IL-1), IL-6, IL-10, and interferon-γ (IFNγ), have been suggested to promote muscle proteolysis, activate the ubiquitin proteasome system, induce contractile dysfunction, and inhibit muscle protein synthesis, but in contrast, they have also been suggested to enhance muscle regeneration following injury [11–16]. Here, TNF is linked to Sepsis.