TDP-43, a protein released in neuronal cells, was observed with features of hyperphosphorylation and ubiquitination in the progression of AD during synaptic and cognitive deterioration (Gao F et al. 2022; Lim L et al. 2016; Mantellatto G M et al. 2024) Transcriptome profiling can unravel pathogenesis mechanisms including neuronal transports, amyloid precursor protein (APP) synthesis and protein interaction during different onset stages of AD. Here, APP is linked to Alzheimer disease.