INS and obesity due to melanocortin 4 receptor deficiency: However, pathway analysis of predicted miRNA regulated male DEGs suggested multiple pathways related to metabolism (Leptin Signaling in Obesity, Insulin Secretion Signaling, Insulin Receptor Signaling, and IGF‐1 Signaling), and cell growth/proliferation and survival (CNTF signaling, PDGF signaling, mTOR signaling, GPCR‐mediated nutrient sensing in enteroendocrine cells) (Figure 4d).