Indeed, although all other methods found upregulation of the PI3K/AKT/MTOR signaling and heme metabolism pathways in the MES-like group and found upregulation of the hedgehog signaling in the NPC-like group, VAM detected upregulation of the PI3K/AKT/MTOR signaling pathway in the NPC-like group, whereas it failed to achieve statistical significance comparing the NPC- and MES-like groups in the two other pathways. The gene discussed is MTOR; the disease is nasopharyngeal carcinoma.