WNT5A and COVID-19: Indeed, the complement system was shown to be hyperactivated in severe SARS-CoV-2 infections (Afzali et al. 2022); SARS-CoV-2 induces DNA damage (Gioia et al. 2023); and WNT5A is upregulated in severe cases of COVID-19 (Choi et al. 2020).