It has been suggested in mice that the beneficial effects of exercise—such as the alleviation of obesity-associated insulin resistance, glucose intolerance, and ectopic lipid accumulation—are abrogated in adipocyte-specific β-klotho (FGF21 receptor) knockout (158), suggesting the important role of FGF21 in mediating the metabolic benefits of exercise (154, 158). Here, FGF21 is linked to Insulin resistance.