E2F1 and cancer: Furthermore, 16 genes (APC2, FZD3, EGFR, TGFBR1, NRAS, PIK3CA, COL4A4, IL2RB, E2F1, GNB4, KRAS, E2F3, IKBKG, SOS1, TP53, and MAPK3) are involved in pathways in cancer, while 11 genes (NRAS, PIK3CA, COL4A4, IL2RB, GNB4, KRAS, IKBKG, SOS1, TP53, EGFR, and MAPK3) are involved in PI3K-Akt signaling pathway and five genes (NRAS, PIK3CA, KRAS, MAPK12, and MAPK3) are involved in VEGF signaling pathway, demonstrating that the important genes identified by the SHAP interpretation of XAT-VAE-Cox model are linked with poor prognosis of NSCLC.