N6‐Methyladenosine (m6A) is one of the most universal RNA modifications among various post‐transcriptional modifications identified in mRNAs and non‐coding RNAs.[39] Recent studies have shown that m6A modification plays a critical role in the regulation of lncRNAs in cancers.[40] In this study, we found that METTL3 mediated m6A modification‐induced upregulation of TUG1, which negatively correlated with the prognosis of HCC patients. This evidence concerns the gene TUG1 and hepatocellular carcinoma.