We further explored the effects of Tug1 upregulation on the tumor immune microenvironments via flow cytometry and found that CD8+ T cells significantly increased and displayed stronger activation phenotypes with more production of IFN‐γ, IL‐2, and TNF‐α in sh‐Tug1 Hepa1‐6 cell‐bearing mice. Here, TNF is linked to neoplasm.