As TUG1 localizes in both the nucleus and the cytoplasm, it also has a highly conserved non‐canonical translation initiation codon (CUG) ORF and could be translated into a microprotein of 153aa in size.[18, 29] We further performed experiments to explore whether TUG1 plays a role in tumor immune regulation by small proteins. This evidence concerns the gene TUG1 and neoplasm.