In addition, the CD8+ T cells in the sh‐Tug1 Hepa1c1c7 cell‐bearing mice also displayed stronger activation phenotypes with more production of IFN‐γ and TNF‐α, and the M1‐like macrophages in the spleens and tumors also clearly increased, which indicated that m6A‐mediated upregulation of TUG1 may be closely related to tumor immunity. This evidence concerns the gene TNF and neoplasm.