PD‐L1 also known as CD274 or B7‐H1, is one of the well‐known immune checkpoints, which presents a critical “don't find me” signal in adaptive immune response: it can bind to PD‐1 to inhibit T cells activation, consequently inducing tumor immune escape.[7] In addition, innate immune cells also play critical roles in the activation of antitumor immunity. The gene discussed is CD274; the disease is neoplasm.