Overall, Tug1 sponges miR‐141 to promote the expression of Pdl1 and regulate the antitumor immune response of CD8+ T cells, and act as miR‐340 sponges to promote the expression of Cd47 and regulate phagocytosis of macrophages, thus ultimately playing a critical role in regulating the antitumor immune response in HCC. This evidence concerns the gene TUG1 and hepatocellular carcinoma.