It also has a highly conserved non‐canonical translation initiation codon (CUG) ORF and could be translated into a microprotein of 153aa in size.[18, 29] To explore whether TUG1 plays a role in tumor immune regulation by small proteins, we transferred Tug1‐ORF into Hepa1‐6 cells, and the results showed that neither Pdl1 nor Cd47 changed at the protein and mRNA levels in Tug1‐ORF‐overexpressed cells (Figure 6O), the overexpression of Tug1‐ORF did not affect tumor growth (Figure 6P). Here, CD274 is linked to neoplasm.