EIF2A and Anxiety: These results indicate the LIPUS plus felodipine@LND treatment facilitated felodipine delivery into brain to shift the cellular signaling in ER URP from the Perk‐eIF2α axis to the Perk‐Nrf2 axis, thus resulting in an alleviation of the anxiety‐like behavior, and an improve cognition ability of mice (Figure 2J).