Nevertheless, our study still leaves some questions unanswered, such as the specific EIF4A3 binding motifs on circHIPK2, other factors involved in EIF4A3‐circHIPK2 complex, the function of circHIPK2 in other cell types, such as immune cells apart from epithelial cells, and the precise mechanism by which circHIPK2 exerts its bidirectional effects on colitis and tumorigenesis. The gene discussed is EIF4A3; the disease is colitis.