The increased risk of CRC in IBD patients has been attributed to long‐standing multiple rounds of intestinal epithelial damage and repair, often in response to excessive inflammation.[22] Also, the occurrence of genetic and epigenetic aberrations in signaling networks is a frequent phenomenon in IBD and CRC.[1, 5] Accumulating data indicated the shared common features between IBD and CRC such as abnormal DNA methylation lineage, RAC1‐dependent cytoskeleton dynamics, and Hippo signaling pathway,[6, 23] although the mechanisms underlying them remain elusive. The gene discussed is RAC1; the disease is colorectal carcinoma.