CCN1 and colorectal carcinoma: Deletion of Ccn1 in ISCs resulted in enhanced ISC proliferation and increased secretory cells at the expense of absorptive cells, suggesting that upregulated Ccn1 may inhibit ISC and secretory cell proliferation while increasing absorptive cells.[9] Overall, CCN1 exerts diverse cellular activities in a cell type‐specific manner, largely through its direct binding to specific integrin receptors.[27] These above studies further support the significant role of the Hippo pathway in the intestinal epithelial of IBD and CRC.