EIF4A3 is a core component of the EJC, which is involved in post‐ transcriptional regulation processes including nonsense‐mediated mRNA decay, mRNA splicing, transport, and translation.[31] Also, EIF4A3 could be recruited by long non‐coding RNAs to regulate the expression of certain proteins in tumors.[31, 32] Notably, circHIPK2 displayed a predominantly cytoplasmic localization in CRC cells, suggesting its potential involvement in post‐transcriptional processes. Here, EIF4A3 is linked to colorectal carcinoma.