Profiling the expression of circRNAs is crucial for the identification and characterization of novel circRNAs, as well as for unraveling their underlying mechanisms and functions.[10a,b] In this study, we uncovered that circHIPK2, originating from the HIPK2 gene, played a pivotal role in both IBD and CRC, marking it as a potential key factor in the shared pathophysiology of these conditions. This evidence concerns the gene HIPK2 and inflammatory bowel disease.