PRKAR2A and colitis: It promoted homeostasis of the intestinal epithelium.[11] PRKAR2A‐derived circRNAs promoted the malignant transformation of colitis and predicted the prognosis of colitis‐associated CRC.[12] Moreover, several circRNAs such as circRHOBTB3, circPTEN1, and circLECRC were shown to play tumor‐suppressive roles in CRC.[13] However, despite these indications, we still lack a comprehensive understanding of the specific circRNAs involved in both IBD and CRC, and their functional roles have not been thoroughly explored.