The Hippo pathway has been shown to influence a broad spectrum of biological processes, particularly in cell growth.[6] And YAP/TAZ, as core components of the Hippo signaling pathway, play crucial roles in both intestinal regeneration and the proliferation of cancer cells.[7b] To this end, we assessed both mRNA and protein levels of YAP and TAZ in the circHIPK2 knockdown cells. The gene discussed is WWTR1; the disease is cancer.