PRPS1 and viral infectious disease: While work from other groups indicated that DRH-1 directs an antiviral RNAi response through interactions with RNAi components, such as DCR-1 and RDE-4, and downstream signaling components RDE-1 and DRH-3 (10, 11, 13), we found that these RNAi factors are dispensable for IPR activation during viral infection (20).