Through conducting intersection analysis, we found nine genes (LUM, VCAN, YAP1, COL5A2, SDC2, TWIST1, CD3G, C1QB, and C3) were intersection genes (Figure 3D), indicating that they had an active effect in modulating the tumor purity, as well as influencing the prognosis of DLBCL patients. This evidence concerns the gene COL5A2 and diffuse large B-cell lymphoma.