IOWH-032 was firstreported as an inhibitor of the human CFTR chlorideand bicarbonate transporter for the treatment of infections relatedto acute watery diarrhea (AWD).35 Sustainedactivation of CFTR by bacterial toxins contributes to AWD since regulatedtransporter function is important for maintaining fluid homeostasisin intestinal epithelial cells. The gene discussed is CFTR; the disease is infection.