RELN variants have been associated with a wide spectrum of neurodevelopmental disorders ranging from recessive forms of NMDs, namely LCH (57) with severe cerebral cortex and cerebellum malformations, to dominant ADLTE (44, 45), or psychiatric disorders such as autism and schizophrenia (41) with no apparent morphological brain abnormalities. The gene discussed is RELN; the disease is neurodevelopmental disorder.