PIK3CA and cerebral cavernous malformation: Finally, PI3K signaling has recently been identified as an important player in CCM [34] but also contributes to PWS [57], SWS [58], venous malformation (VM and VMCM) [60,61], Klippel-Trénaunay syndrome (KTS) [62–64], HHT [65], and multiple PIK3CA syndromes which have associated vascular anomalies [66,67].