Interestingly, KRIT1 deletion in the intestinal epithelium in vivo did not exacerbate CCM-like lesion formation in KRIT1 endothelial knockout mice [104], in contrast with epithelial deletion of PDCD10 (in PDCD10 endothelial knockout mice), which increased lesion formation and reduced the thickness of the colonic mucosal barrier [108]. Here, PDCD10 is linked to cerebral cavernous malformation.