NGF and Familial prostate cancer: Nerve growth factor has the capacity to modulate inflammatory and neuropathic pain conditions.12 Furthermore, NGF can trigger the activation of tropomyosin receptor kinase A (TrkA), which could initiate the proliferation and progression of prostate tumor cells through the interaction between TrKa and the androgen receptor, a pivotal component in prostate cancer proliferation.13 Therefore, NGF could mediate both pain and tumor growth.