APOE and endothelial dysfunction: In non-treated ApoE/LDLR−/− mice fed with a control diet at the age of 24 weeks, endothelial dysfunction was present as evidenced by the loss of vasodilatation response and paradoxical vasoconstriction (Ach-induced response: − 9.7 ± 2.9% in BCA and − 25.7 ± 4.5% in LCA, Fig. 1).