Although minimally expressed in normal tissues and rarely in tissues near cancer [20], LGMN is usually overexpressed in the microenvironments of the various solid tumors [21] as breast cancer, colorectal cancer, ovarian cancer, etc. Extensive studies have shown that as LGMN is closely related to the tumor metastasis, diffusion, and invasion, and considered as a potential biomarker indicative of poor prognosis [22]. This evidence concerns the gene LGMN and colorectal cancer.