Retinal PHF-tau deposition strongly associated with brain NTs burden and ABC scores (Fig. 6e, f; rS = 0.71, P = 0.0011 and rS = 0.69, P = 0.0014, respectively), and moderately with Braak staging, CAA, brain atrophy, and NFTs severity scores (Table 3). The gene discussed is MAPT; the disease is Brain atrophy.