To investigate the burden and spatiotemporal distribution of AD-related abnormal tau isoforms (Fig. 1a) in the retina, we prepared retinal cross-sections from the ST and IT regions in a cohort of patients with a premortem diagnosis of AD dementia (n = 34, mean age 83.88 ± 12.67 years, 21 females/13 males) or MCI (due to AD; n = 11, mean age 89.55 ± 6.12 years, 7 females/4 males), with postmortem neuropathological confirmation of AD, along with individuals with NC (n = 30, mean age 81.43 ± 9.82 years, 16 females/14 males). The gene discussed is MAPT; the disease is Alzheimer disease.