Some pathological changes associated with AD, such as Aβ deposits, tau isoforms, vascular damage, and atrophy, were more frequently detected or had a greater impact in the superior temporal (ST) or inferior temporal (IT) retinal regions of AD patients compared to controls [7, 20, 31, 43, 44, 47, 50, 74]. The gene discussed is MAPT; the disease is Alzheimer disease.