Compared with NC control retinas, we identified intense and diffuse-like T22+ Oligo-tau signals in the AD and MCI retinas, when labeled in combination with the pre-synaptic marker, vesicular glutamate transporter 1 (VGLUT1) and DAPI (blue) for nuclei (Fig. 2a, upper panel), or with DAPI (Fig. 2a, lower panel). The gene discussed is MAPT; the disease is Alzheimer disease.