Retinal tangles, as revealed by MC-1 and Bielschowsky silver staining, also appear as paperclip tau formations resembling NFTs (Fig. 1b,and e, right panel), as observed in the AD brain by Gallyas and Bielschowsky silver staining (Fig. 1d, ande, left panel; see additional Bielschowsky silver stain images across retinal layers and in paired brain tissues from other AD patients in Suppl. Here, ATP7A is linked to Alzheimer disease.