Studies have revealed that overexpression of WDHD1, which is crucial for chromosome formation, transcription, DNA replication, and cell death [11], has been linked to the proliferation of cancerous cells in several cancers, including non-small cell lung cancer (NSCLC) [12], esophageal cancer [11], gallbladder cancer [13], etc. Evidence suggests that WDHD1’s regulation of the cell cycle contributes to the development of laryngeal squamous cell cancer (LSCC) [13, 14]. This evidence concerns the gene WDHD1 and esophageal cancer.