KRAS and infection: Similarly, incubation of mitochondria with the full-length NS3 construct, NS3prohel, promoted a 28.4% decrease in pyruvate/malate-dependent respiration (S.D. ± 3.2%, P = 0.0026) (Fig. 3C), showing that this effect is also observed using the native protein and, thus, can occur in the context of the infection.