IFNG and cryptococcosis: Protection against experimental cryptococcosis can be obtained by immunization with cryptococcal strains missing virulence factors (such as chitosan, capsule, sterylglucosidase, and the F-box protein, Fbp1) or engineered to heterologously express interferon-γ (IFNγ) or overexpress the transcription factor Znf2 (8, –, 15).