Since fibroblast recruitment is progressively increased in cSCC, we wondered whether CRELD2, a key paracrine factor involved in the recruitment and polarization of tumor‐promoting CAFs in autochthonous mammary tumors (Boyle et al., 2020), may also be involved in regulating the enhanced infiltration of fibroblasts into cSCCs. The gene discussed is CRELD2; the disease is neoplasm.