There was a higher percentage of naive CD4+ cells (CD62L+/CD44−), a lower percentage of effector CD4+ cells (CD62L−/CD44+) in CKD and CKD+PD groups, and a higher percentage of central memory CD4+ cells (CD62L+/CD44+) in the CKD+PD group versus control (Figure 4B). The gene discussed is CD44; the disease is chronic kidney disease.