NT5E and familial pancreatic carcinoma: This was demonstrated with the administration of IL-12 (Mills et al., 2019) or inhibition of CD73 (encoded by NT5E), a surface enzyme involved in the conversion of AMP to the immunosuppressive metabolite adenosine (Ye et al., 2023), in both orthotopic transplant models using syngeneic mouse pancreatic cell lines and spontaneous KrasG12D- and Trp53R172H-driven GEMMs of pancreatic cancer.