SIRPA and familial pancreatic carcinoma: For example, depleting the membrane glycoprotein SIRPα (encoded by SIRPA) from macrophages can enhance the efficacy of radiotherapy in subcutaneous tumours resulting from transplant of syngeneic mouse pancreatic cancer cell lines, as SIRPα-deficient macrophages are able to adopt a pro-inflammatory anti-tumour response following irradiation, promoting enhanced CTL and natural killer cell infiltration with limited fibrosis (Bian et al., 2021).