In the reverse MR analysis examining the relationship between SCZ and 91 inflammatory cytokines, we observed the following outcomes: Elevated levels of Leukemia Inhibitory Factor (LIF) were linked to an increased risk of schizophrenia (OR = 1.040, 95% CI: 1.003–1.078, p = 0.033, FDR = 0.165, via IVW). The gene discussed is LIF; the disease is schizophrenia.