Moreover, mediation analyses showed significant effects for TestASV_6 (Subdoligranulum) abundance (Proportion mediated (%): 7.75) and G_Bacteroidetes prevalence (Proportion mediated (%): 5.16) on TSG-6-mediated risk for RA (Figure 4; Table 2; Supplementary Table 10). Here, TNFAIP6 is linked to rheumatoid arthritis.