The influence on platelet desialylation is noteworthy; (ii) Abnormal disorders of the autoimmune system: In pathological states, autoimmune system disorders in ITP patients result in the generation of corresponding antibodies such as anti-GPIIb/IIIa, anti-GPIbα, anti-GPIb/IX and anti-GPIa/IIa antibody. This evidence concerns the gene GP1BA and autoimmune thrombocytopenic purpura.