Cytokines like Interleukin 1 Beta (IL-1β), IL-6, C-X-C Motif Chemokine Ligand 8 (CXCL8 or IL-8), and Tumor Necrosis Factor Alpha (TNF-α) were found to be higher in individuals with advanced CRC (23). This evidence concerns the gene IL1B and colorectal carcinoma.