However, recent studies have revealed that YAP can function as a context-dependent tumor suppressor in several types of cancer including hematological cancers (21), estrogen receptor α (ERα) positive breast cancer (22, 23), androgen receptor (AR) positive prostate cancer (24), and VHL negative clear cell renal cell carcinoma (ccRCC) (25). The gene discussed is ESR1; the disease is nonpapillary renal cell carcinoma.