The localization of Usher proteins (PCDH15 and Whirlin) as well as actin filament-related proteins in canine photoreceptors aligns with the patterns reported in NHP photoreceptors, suggesting that a canine IRD model may provide valuable insights into pathogenesis of Usher syndrome, for which effective pathological models are challenging to develop in rodents. This evidence concerns the gene WHRN and Usher syndrome.