Reduced killing by APN−/− AMs was confirmed in vivo in FLARE-infected neutropenic mice, with a significant difference in conidial viability by day 3 post-infection (Figs. 3E and 3F), while uptake of 1 μm inert particles was not significantly different between wild-type and APN−/− AMs (Fig. 3G). Here, ANPEP is linked to infection.