ANPEP and infection: In contrast to WT mice, mortality was 100% in APN−/−, AdipoR1−/−, and AdipoR2−/− mice, with mortality beginning on day 2 post-infection and 100% by day 6 p.i. (Fig. 1B), with extensive lung hyphal growth and peri-bronchoalveolar inflammation (Fig. 1C) and increased fungal burden as measured by qPCR of fungal DNA (Fig. 1D) and image quantification of fungal GMS staining (Fig. 1E).