In contrast to WT mice, mortality was 100% in APN−/−, AdipoR1−/−, and AdipoR2−/− mice, with mortality beginning on day 2 post-infection and 100% by day 6 p.i. (Fig. 1B), with extensive lung hyphal growth and peri-bronchoalveolar inflammation (Fig. 1C) and increased fungal burden as measured by qPCR of fungal DNA (Fig. 1D) and image quantification of fungal GMS staining (Fig. 1E). The gene discussed is ADIPOR2; the disease is infection.