Moreover, mutations in CCND1, which prevent the degradation of cyclin D1 by AMBRA1, a substrate receptor (SR) of a CUL4-RING ubiquitin ligase (CRL4) complex that targets all three D-type cyclins for proteasome-mediated degradation, have been reported in a variety of tumor types10–12. The gene discussed is CCND1; the disease is neoplasm.