The RNA-seq analysis of the egg-injected samples also showed contrasting results, with the upregulation of Esr1 (p-adj = 0.125) and downregulation of Esr2 (p-adj = 0.012) (Supplementary 5), warranting further investigation addressing the effect of infection on estrogen receptor signaling and its role in carcinogenesis. The gene discussed is ESR1; the disease is infection.