TNF and cancer: To our knowledge, the active ingredients of BHP PM-SS may regulate Glutathione metabolism, Pyrimidine metabolism, Arginine biosynthesis and Amino acid sugar and nucleotide sugar metabolism to ameliorate ALI, by acting on the targets of AKT1, TNF, EGFR, JUN, HSP90AA1 and STAT3, which partly occurred in PI3K-AKT signaling pathway, MAPK signaling pathway and Pathway in cancer.