Lutein supplementation in rats fed with a high-fat diet (HFD), a model of MASLD, recovered liver function, improved lipid accumulation, and restored hepatic lipid metabolism and insulin signaling through regulation of the protein Sirtuin 1(SIRT1), suggesting that lutein supplementation plays a potential role in preventing hepatic dyslipidemia and insulin resistance (Qiu et al., 2015). The gene discussed is SIRT1; the disease is Insulin resistance.