The interaction between the DD domain of RIPK1 and the transcription activation domain of Sox9 prevents the transcriptional activation of pro-survival and stemness-related genes by the Sox9 transcription factor and block RIPK1-mediated cancer cell death by necroptosis in the cytoplasm, leading to the survival of CSCs in high-grade ovarian carcinoma [41]. The gene discussed is RIPK1; the disease is ovarian carcinoma.