Parts of the Carica papaya plant, such as the leaf, seed, fruit, and stem, have been used as traditional remedies for many bodily ailments. Carica papaya leaf extract has been used in the treatment of dengue fever, where it has been shown to have inhibitory activity against the NS2B-NS3 serine protease, which is necessary for viral replication [15]. The gene discussed is KRAS; the disease is dengue disease.