We found a significant association between DRB1*11, DRB1*15, DQA1*0103, DQA1*0401, DQB1*0301 and DQB1*0401 and high-grade cervical intraepithelial neoplasia (CIN2+). This evidence concerns the gene HLA-DRB1 and cervical intraepithelial neoplasia.