For instance, Eichstaedt et al. analyzed PAH candidate genes in HAPE-prone families and mountaineers by next-generation sequencing technology, and identified the association between PAH-related pathogenic mutations in JAK2 gene and HAPE for the first time, and found other pathogenic variants in some HAPE-prone mountaineers, suggesting that genetic predisposition is closely related to PAH signaling pathways (Eichstaedt et al., 2020). This evidence concerns the gene JAK2 and pulmonary arterial hypertension.