Noteworthy keywords such as nitric oxide (26.11, 2004–2016), substance P (25.89, 2004–2015), receptor antagonist (20.95, 2004–2015), and extracerebral circulation (17.12, 2004–2009) represent the foundation and the starting point of migraine treatment research over the past two decades. This evidence concerns the gene TAC1 and migraine disorder.