Specific keywords within these clusters include ‘migraine,’ ‘CGRP,’ ‘headache,’ and ‘trigeminovascular system’ in the red cluster; ‘double-blind,’ ‘calcitonin gene-related peptide,’ ‘efficacy,’ ‘safety,’ and ‘preventive treatment’ in the green cluster; and ‘randomized controlled-trial,’ ‘monoclonal-antibody,’ and specific drug names like ‘telcagepant,’ ‘ubrogepant,’ ‘atogepant,’ and ‘rimegepant’ in the blue cluster. The gene discussed is CALCA; the disease is migraine disorder.