The distribution across countries and institutions, journal quality, and author contributions of these 1,821 articles were meticulously assessed using analysis and visualization tools, including CiteSpace, VOSviewer, and the R package “bibliometrix.” Additionally, we employed citation burst analysis, cluster analysis, and keyword analysis to identify the current hotspots of focus and emerging trends in CGRP-related research in migraine. The gene discussed is CALCA; the disease is migraine disorder.