•CB promote formation of CB1-R/GABA-A-R complex → ↓ efficacy of GABA-A-R and interferes with GABAergic neurotransmission → Increase inhalation and intravenous anesthetic requirements (51, 163, 164)•CB1_R activation by preoperative CB exposure → ↓ release of acetylcholine in neocortex → transient postoperative cognitive deficit•CB provokes changes in CYP enzymatic system expression and activity → acceleration in metabolic degradation of propofol and reducing its hypnotic effects (154, 156, 158–161). This evidence concerns the gene CNR1 and Cognitive impairment.