While in the sarcopenia dataset, ACE (AUC: 0.742), ALDH1L2 (AUC: 0.748), CYP1A1 (AUC: 0.765), PYGL (AUC: 0.73), KLF5 (AUC: 0.803), PHGDH (AUC: 0.76), IDO1 (AUC: 0.72), EME1 (AUC: 0.703), MYBL2 (AUC: 0.711), BCL6 (AUC: 0.705), and ESM1 (AUC: 0.746) demonstrated better diagnostic performance for distinguishing sarcopenia from healthy individuals. This evidence concerns the gene ESM1 and sarcopenia.