In sharp contrast to the low frequency among the aforementioned hematological malignancies, IKZF1 alterations is of much higher frequency in BCP-ALL (19, 22), particularly in kinase and cytokine- receptor signaling activating leukemias including Ph+ALL and Ph-like ALL (59, 60, 65–68). The gene discussed is IKZF1; the disease is acute lymphoblastic leukemia.