and others reported that IKZF1 alterations is frequent in BCP-ALL, about 15% in pediatric patients and increasing to 30%-50% in adult patients, and remarkably higher in high-risk subtypes, notably, the frequency is as high as 84% and 70% in adult Ph+ALL and Ph-like ALL, respectively (19, 22, 59, 60, 65–68, 84, 85). Here, IKZF1 is linked to acute lymphoblastic leukemia.