ABL1 and acute lymphoblastic leukemia: As in acute lymphoblastic leukemia, especially of high-risk B-cell-precursor ALL (BCP-ALL), in which IKZF1 gene mutation is of high frequency (19, 20), such as BCR-ABL positive ALL and BCR-ABL-like ALL, genetic alteration of IKZF1 gene is associated of poor outcome (21–23) and confers resistance in conventional chemotherapy (24, 25).