The ATM germline variants were also significantly associated with subtypes overexpressing HER2 and/or HR, which is consistent with previous studies describing intermediate- to high-grade, HR+ disease and potentially higher rates of HER2 positivity and lymph node involvement associated with ATM germline variants (39, 40), as well as reduced recurrence time in invasive HER2+ BC patients (39). The gene discussed is ERBB2; the disease is breast cancer.