While there was no definitive marker for proteinopathies such as TDP-43 in ADNI, I used several suggestive imaging and cognitive assessments to provide some indications for TDP-43 pathology.35 I explored the possibility of limbic-predominant age-related TDP-43 encephalopathy (LATE) copathology in the susceptible groups. The gene discussed is TARDBP; the disease is proteostasis deficiencies.