MAPT and Mental deterioration: While it is believed that both Aβ and tau pathology might affect FC, there might be a more critical role for tau considering the fact that it is more strongly associated with cognitive decline and transneuronal spreading.38-40 A previous study demonstrated that lower FC in the DMN and the salience network, which are Aβ preferentially deposition areas, is associated with higher tau accumulation in the inferior temporal cortex.41 Moreover, the result of this study revealed that the association between tau and FC might be modulated by the Aβ pathology.