MAPT and early-onset autosomal dominant Alzheimer disease: Furthermore, the findings from a recent task-based fMRI study in individuals without cognitive impairment and with mixed Aβ status suggest that the tau accumulation in the memory system of the MTL is linked to increased FC in both the MTL and the posteromedial hubs of the DMN.42 It is worth noting that the initial accumulation of both tau and Aβ, despite occurring in different brain regions, seems to be negatively correlated with cognitive function in the preclinical stage of Alzheimer’s disease.