MAPT and Alzheimer disease: Efficient information transfer along the neuronal groups within functionally specialized brain areas results in normal cognitive function.11,12 Disruption of this information transfer leads to cognitive dysfunction in multiple neurological disorders including Alzheimer’s disease.13,14 The Aβ plaques and tau neurofibrillary tangles result in the progressive degeneration and shrinkage of neurons, along with synaptic dysfunction in distinct cortical and subcortical brain regions.