MAPT and early-onset autosomal dominant Alzheimer disease: BIN1 encodes bridging integrator 1 and is the second strongest signal associated with Alzheimer’s disease, but was not genome-wide significantly associated with LBD-D in this study (P = 2.276e−05).54 Increased BIN1 expression is associated with a higher load of tau in the Alzheimer’s disease brain, but not amyloid.55 While some studies found the tau load to be a correlate of dementia in Parkinson’s disease and dementia with Lewy bodies, other studies have not.