The average Rp on colocalization of hTau in Iba1+ microglia cells were evaluated on ROI from multiple brain sections, which was significantly higher in old AD versus in WT mice (Fig. 5A and G), P < 0.01, unpaired 2-tailed t-test with equal variance, n = 3–5 mice/group. The gene discussed is AIF1; the disease is Alzheimer disease.