Deposits of tauopathy distributed in entorhinal cortex, hippocampus, neocortex and amygdala in young 3xTgAD mice (Fig. 3A, C and E),33 recapitulate tau pathology manifested in human AD as Braaks stages I–III.41 Notably, amyloid-β pathology (extracellular diffuse or neuritic plaques) appeared early within the hippocampus (Fig. 3F) but was not evident in the BF until a later stage (Supplementary Fig. 3). This evidence concerns the gene MAPT and Alzheimer disease.